非同聚合物精神分裂素在伤口愈合中的作用和机制

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Peixuan Lei¹, Yaying Yu¹, Fenrou Chen²

¹School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Pharmaceutical Preparations Research and Evaluation, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.

International journal of biological macromolecules

|July 8, 2025

概括

精神分裂素 (SPG),一种天然的多糖,通过促进细胞增殖,迁移和抗氧化活性,显著加速伤口愈合. 这项研究证明了SPG.

科学领域:

生物化学和分子生物学
生物材料科学生物材料科学
皮肤病学皮肤病学

背景情况:

斯基索菲兰 (SPG) 是来自斯基索菲伦 (Schizophyllum) 共同体的多糖,具有抗氧化和抗炎性质.
关于用于伤口修复的非同聚合物SPG的研究有限.

研究的目的:

研究SPG在促进皮肤伤口愈合方面的疗效和机制.
评估SPG对细胞增殖,迁移和氧化应激的作用,在体外和体内.

主要方法:

SPG 是通过 Schizophyllum 社区 5.43.3 的液体发酵来生产的.
在体外研究中评估了SPG对HaCaT和HUVEC细胞增殖,迁移和氧化应激的影响.
在体内研究中使用了BALB/c小鼠的全厚皮肤伤口模型来评估SPG的治疗潜力.

主要成果:

SPG显著增强了HaCaT和HUVEC细胞的增殖和HUVEC细胞的迁移.
SPG促进了细胞周期调节因子,细胞外矩阵 (ECM) 重塑和抗氧化基因表达.
SPG减少了H2O2诱导的氧化应激,并在小鼠中实现了96.65%的伤口愈合率,超过了商业水凝敷料.

结论:

通过涉及细胞循环调节,ECM重塑和抗氧化基因增强的机制,SPG有效地促进皮肤伤口愈合和上皮质化.
SPG显示出作为天然治疗剂的显著潜力,用于伤口愈合和组织再生.
这些发现支持开发基于SPG的皮肤修复治疗方法.

关键词:

具有抗氧化活性的抗氧化剂.细胞的增殖和迁移.精神分裂症的人.伤口愈合伤口愈合

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