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识别与Mytilus galloprovincialis中的微塑料暴露相关的microRNA-mRNA调节网络

Giovanni Annona¹, Concetta Montanino², Bruna De Felice²

¹Research Infrastructures for Marine Biological Resources (RIMAR), Stazione Zoologica Anton Dohrn, Naples, Italy.

|July 8, 2025

概括

微塑料污染通过改变microRNAs (miRNAs) 和它们的基因对的影响. 这影响了关键的生物过程,对海洋生态系统构成风险,并可能通过食用海鲜对人类健康造成风险.

科学领域:

环境毒理学环境毒理学
海洋生物学海洋生物学
分子生物学分子生物学

背景情况:

塑料碎片,包括微型和纳米塑料,在水生环境中普遍存在.
塑料污染破坏了海洋动物生理学,并在食物链中积累,对人类健康构成风险.
贝是全球消费的海鲜,也是微塑料转移到人类的潜在载体.

研究的目的:

为了研究微塑料颗粒对Mytilus galloprovincialis微RNA (miRNA) 调制的影响.
为了确定受微塑料暴露影响的miRNA-mRNA调节网络.
了解海洋生物中微塑料毒性背后的分子机制.

主要方法:

成年 (Mytilus galloprovincialis) 暴露在不同度和时间点的聚烯微粒中.
分析了精选的微RNAs (miRNAs) 和它们的目标信使RNAs (mRNAs) 的表达水平.
生物信息学方法被用来识别miRNA-mRNA调节网络.

主要成果:

微塑料暴露显著调节了贝中特定miRNAs的表达.
微RNA表达的改变与参与免疫反应,细胞刺激,蛋白质相互作用,细胞亡和细胞死亡的目标基因的变化有关.
一个独特的miRNA-mRNA调节网络被确定作为对微塑料暴露的反应.

结论:

微塑料诱导miRNA表达和下游基因调节的显著变化.
这些分子变化凸显了微塑料破坏基本生物过程的潜力.
这些发现有助于理解与微塑料污染相关的生态和潜在人类健康风险.

关键词:

海洋污染海洋污染贝贝贝贝贝贝塑料碎片塑料碎片塑料碎片这就是为什么 miRR 是 miR.miRNA的目标基因是 miRNA的目标基因.miRNA/microRNA 是一个微型RNA.

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