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慢性失眠中不同频段的中心度变化:休息状态fMRI研究

Jurong Ding¹, Pan Yang¹, Zhiyuan Xu¹

¹School of Automation and Information Engineering, Sichuan University of Science and Engineering, Zigong 643000, PR China; Intelligent Perception and Control Key Laboratory of Sichuan Province, Sichuan University of Science and Engineering, Zigong 643000, PR China.

Neuroscience letters

|July 8, 2025

概括

慢性失眠 (CI) 涉及广泛的,频率特定的大脑活动变化. 休息状态fMRI揭示了不同大脑区域的神经活动的改变,为CI神经生物学提供了洞察力.

科学领域:

神经科学是一个神经科学.
医疗成像医学成像
睡眠医学睡眠医学

背景情况:

异常的自发神经活动与慢性失眠 (CI) 有关.
之前的神经成像研究表明CI的大脑发生了广泛的变化.
在CI中这些神经活动变化的频率特异性仍然在很大程度上未被探索.

研究的目的:

研究慢性失眠患者自发神经活动的频率特定变化.
利用静止状态功能磁共振成像 (rs-fMRI) 和度中心性 (DC) 分析来检查不同频段的神经活动.

主要方法:

休息状态功能磁共振成像 (rs-fMRI) 在37名CI患者和20名健康对照组 (HCs) 中使用.
在四个频段进行了度中心性 (DC) 分析:慢-5 (0.012-0.031 Hz),慢-4 (0.031-0.081 Hz),慢-3 (0.081-0.224 Hz) 和慢-2 (0.224-0.25 Hz).
部分相关性分析探讨了异常DC值和临床评估之间的关系.

主要成果:

CI患者在皮层 (缓慢-5带) 和左侧中圈 (缓慢-4带) 呈现减少的DC.
在缓慢-3和缓慢-2频段的前额皮质中观察到DC的减少.
在多个频段的右中额头和上额头,以及右带状 (缓慢-3频段) 中,注意到DC增加.
在右中额头直径DC (缓慢-4带) 和迷你精神状态检查得分之间发现了正相关性.

结论:

慢性失眠的特点是大脑活动的广泛和频率特定的改变.
这些发现为慢性失眠的神经生物学基础提供了关键的见解.
这项研究强调了考虑频率特定分析对于理解CI大脑机制的重要性.

关键词:

慢性失眠症是什么慢性失眠症中心性的程度.频段频段频段频段频段休息状态的fMRI.

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