在患有遗传性抗血缺乏症的患者怀孕期间如何管理静脉血栓栓塞的风险?
Laetitia Mauge1,2, Hugo Madar3, Julie Carré4,5
1Service d'Hématologie biologique, AP HP, Hôpital Européen Georges Pompidou, Paris, France.
Thrombosis and haemostasis
|July 8, 2025
概括
遗传性抗血缺乏症 (ATD) 会增加血栓的风险,尤其是在怀孕期间. 管理需要仔细考虑抗凝和抗血栓替代的安全结果.
科学领域:
- 血液学 血液学 血液学
- 产科 产科 产科 产科 产科
- 血栓形成的管理
背景情况:
- 遗传性抗血缺乏症 (ATD) 显著增加了静脉血栓栓塞的风险.
- 怀孕进一步放大了这种风险,需要采取预防措施.
- 当前关于孕妇ATD患者血栓预防的指导方针是异质的,支持文献有限.
研究的目的:
- 审查和提出管理策略,以预防ATD孕妇的血栓形成.
- 在怀孕和产后期间提供关于抗凝血和抗血栓替代的指导.
- 为了应对管理这些复杂案件所面临的挑战.
主要方法:
- 法国血栓和血液静止学会 (SFTH) 进行了一项全面的文献审查.
- 审查重点关注的是血栓形成风险,抗凝剂治疗,抗血栓缩剂和周围治疗管理.
- 根据审查的文献,制定了管理建议.
主要成果:
- ATD具有相当大的血栓形成风险,特别是在与怀孕相结合时.
- 抗凝固药物治疗和抗血素替代需要谨慎的剂量,监测和时间.
- 产前期管理策略对于预防并发症至关重要.
结论:
- 在有ATD的孕妇患者中管理血栓预防是复杂的.
- 一种涉及血液学家,产科医生和麻醉师的多学科方法是必不可少的.
- 建议咨询专家中心,以获得最佳的患者护理和管理.
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