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Updated: Sep 16, 2025

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
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塔普西加金触发了基性白血病细胞中的非亡性,独立于卡斯帕斯的编程细胞死亡

Philip Steiner1, Korollus Melek2, Ancuela Andosch3,4

  • 1Institute of Pharmacology, Faculty of Medicine, Johannes Kepler University Linz, Linz, Austria. philip.steiner@jku.at.

Cell death discovery
|July 8, 2025
PubMed
概括

塔普西加金诱导一种名为自闭症的非亡性细胞死亡,挑战其作为经典亡诱导者的作用. 这一发现影响了平衡和癌症治疗的研究.

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Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
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Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
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