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内定向连接将前额叶皮层的子区域与严重抑郁联系起来

John Myers¹, Jiayang Xiao², Raissa K Mathura²

¹Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA. john.myers@bcm.edu.

Nature communications

|July 8, 2025

概括

重度抑郁症可能源于前额叶皮层的抑制. 增加的三角带连接和半球失衡与恶化的抑郁症状相关.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
计算神经科学是一种神经科学.

背景情况:

大型抑郁症 (MDD) 假设涉及皮质消抑制.
前额叶皮层 (PFC) 的子区域被认为是这种无抑制的来源.
这种假设在患有MDD的人类中进行直接测试是有限的,因为内记录存在挑战.

研究的目的:

通过检查前额叶皮层活动来研究MDD的神经基础.
测试MDD涉及皮质消抑制和半球间不平衡的假设.
为了将内记录与抑郁症症状严重程度的每日波动相关联.

主要方法:

在患有MDD的患者中,利用了来自背侧前额叶皮层 (DLPFC),轨道前额叶皮层 (OFC) 和前带皮层 (ACC) 的内记录.
自我报告的抑郁症症状严重程度的测量每日波动.
分析了三角洲频段 (1-4 Hz) 内的定向连接性和半球间的功能平衡.

主要成果:

在负面情绪状态期间,三角洲频段的定向连接暂时增加.
症状严重程度与左侧和右侧PFC之间的不平衡连接模式相关.
研究结果表明,在MDD中,前额外消抑制和功能半球失衡之间存在联系.

结论:

这项研究支持这样一个假设,即前额部消抑制会导致抑郁症的恶化.
前额叶皮质半球之间的功能失衡与MDD有关.
内录音提供了对抑郁症情绪调节神经动态的洞察.

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