老年人的肺功能和运动认知风险综合征
Xiaofu Du1, Jingyi Sun2, Suhang Song3
1Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, 310,051, Zhejiang, China.
Scientific reports
|July 8, 2025
概括
良好的肺功能 (PF) 与发展运动认知风险综合征 (MCR) 的风险较低有关,这是痴呆症的前体. 保持肺部健康可能有助于预防老年人MCR.
科学领域:
- 老年学是一门学科.
- 肺部病理学 肺部病理学
- 神经学 神经学
背景情况:
- 肺功能 (PF) 与神经退行性疾病有关.
- PF和运动认知风险综合征 (MCR) 之间的联系,这是一个前发性痴呆阶段,尚未得到充分证实.
研究的目的:
- 研究肺功能与老年人发展运动认知风险综合征的风险之间的关联.
主要方法:
- 利用了来自英国长度老龄化研究 (ELSA) 的数据.
- 使用1秒内强制呼气量 (FEV1),强制生命能力 (FVC),峰值呼气流量 (PEF) 和复合的PF (CPF) 评分来评估PF.
- 通过主观记忆抱怨和慢步速度来定义MCR.
- 采用Cox比例危险回归模型进行分析,平均随访时间为10年.
主要成果:
- 较高的复合PF水平与发生MCR的风险显著降低有关.
- 具体来说,CPF的第三层显示出0.65的危险比率 (95% CI:0.47到0.89,P=0.008) 与最低的第三层相比.
- 持续的CPF分析显示,危险比率为0.73 (95% CI:0.62至0.85,P<0.001).
- 在FVC,FEV1,PEF和MCR风险之间观察到不良关联.
结论:
- 肺功能升高与发展运动认知风险综合征的风险降低有关.
- 监测PF和实施干预措施来维持肺部健康可能是预防老年人MCR的策略.
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