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重组单克隆抗体siltartoxatug与血衍生的人类结免疫球蛋白对结:一个随机的,双盲的,主动控制的,第三阶段试验

Zijing Liang1, Si Liu2, Wei Guo1

  • 1Department of Emergency, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Nature medicine
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PubMed
概括

作为一种新型重组单克隆抗体,Siltartoxatug在风预防中表现出优于人免疫球蛋白 (HTIG) 的疗效和安全性. 这提供了一个有前途的替代方案,以解决全球短缺的HTIG.

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Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...