与Q热相关的胆囊炎:病例报告和系统审查
Aymery Stheme de Jubécourt1,2, Marie Hocquart3, Olivier Picaud3
1Institut Hospitalo-Universitaire Méditerranée Infection, 19-21 boulevard Jean Moulin, Marseille, 13005, France. aymery.Stheme-de-jubecourt@ap-hm.fr.
概括
燃烧性菌 (coxiella burnetii) 引起结核胆囊炎,通常与Q热有关. 诊断依赖于血清学和PCR,而多西环林是这种感染的主要治疗方法.
科学领域:
- 传染性疾病 传染性疾病
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 菌 (coxiella burnetii) 是一种未被认可的结算性胆囊炎的原因.
- 已经确定了与IgG抗心素的剂量依赖性关联.
- 长期管理和Q热相关胆囊炎的并发症需要进一步调查.
研究的目的:
- 描述一个地方流行地区的Coxilla burnetii胆囊炎病例.
- 对与Q热相关的C. burnetii胆囊炎病例进行系统审查.
- 突出C. burnetii胆囊炎的诊断和治疗策略.
主要方法:
- 来自特有地区的外科病例描述.
- 对C. burnetii胆囊炎病例的系统审查.
- 分析患者数据,包括人口统计,症状,诊断测试和治疗结果.
主要成果:
- 包括27名患者,其中11.1%为儿童.
- 大多数病例发生在急性Q热期间;一名患者患有慢性胆囊炎.
- 胆囊PCR在100%的测试病例中证实了C. burnetii;只有11.1%的病例是结算性的.
- 典型的表现包括结算性胆囊炎,类似流感的疾病,狼抗凝剂,抗心皮素抗体和血小板狭窄症.
结论:
- 血清学和PCR (血液,胆囊活检) 对于诊断C. burnetii胆囊炎至关重要.
- 怀疑是一种炎症和/或自身免疫机制.
- 东环素是推的第一线治疗;未来的研究应该探索东环素和化,以预防抗脂抗体阳性患者的慢性疾病.
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