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对细胞循环,衰老和新陈代谢的图书识别见解:从分子机制到临床影响
Yue Pan1,2, Hao Liu3, Jianni Chen1,4
1Department of Thoracic Surgery and Oncology, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, No. 151, Yanjiang Road, Guangzhou, 510120, People's Republic of China.
Biogerontology
|July 8, 2025
概括
研究表明,细胞循环调节,衰老和新陈代谢越来越多地一起研究,特别是在癌症和神经退行性疾病方面. 这种交叉点是未来瘤治疗的关键.
科学领域:
- 老年学是指老年学的学科.
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 细胞循环调节,衰老和新陈代谢是基本的生物过程.
- 它们的相互作用对于理解正常生理学和疾病发病过程至关重要.
- 跨学科的研究对于促进老年病学和临床瘤学的发展至关重要.
研究的目的:
- 系统地绘制关于细胞循环,衰老和新陈代谢的学术成果.
- 确定这个跨学科领域的研究趋势,合作和专题集群.
- 突出这一研究在瘤学中的翻译潜力.
主要方法:
- 在2004年至2023年期间,利用Web of Science核心集合对698篇论文进行了图书统计分析.
- 使用VOSviewer和CiteSpace.Space可视化协作网络,地理分布和主题集群.
- 关键词分析以确定关键研究主题和集群.
主要成果:
- 从2019年到2022年,细胞周期,衰老和新陈代谢的交叉点的研究显著增加.
- 美国和中国是主要的贡献者,有着强大的国际合作.
- 关键的研究集群包括神经退行性生物标志物,氧化损伤,癌细胞循环中断,衰老癌症表观遗传学和代谢应激反应.
结论:
- 衰老中的代谢转变影响细胞修复和衰老,使研究向分子洞察力迈进.
- 了解这些分子和遗传相互作用对于推进瘤学至关重要.
- 未来的研究应该专注于基于细胞周期动态和遗传特征的个性化癌症治疗.
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