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相关概念视频

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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One-Compartment Open Model for IV Bolus Administration: Estimation of Elimination Rate Constant, Half-Life and Volume of Distribution01:09

One-Compartment Open Model for IV Bolus Administration: Estimation of Elimination Rate Constant, Half-Life and Volume of Distribution

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The one-compartment open model is a simplified approach used in pharmacokinetics to understand the distribution and elimination of a drug administered through an intravenous bolus. This model assumes rapid drug dispersal throughout the body and elimination using a first-order process. Key pharmacokinetic parameters, such as the elimination rate constant (k), half-life (t1/2), and the apparent volume of distribution (Vd), can be estimated from this model. The elimination rate is calculated...
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Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
269
Drug Dosage Regimen: Overview01:15

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A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
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One-Compartment Open Model for IV Bolus Administration: Estimation of Clearance00:56

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Clearance is a key pharmacokinetic parameter that quantifies the volume of body fluid from which a drug is entirely removed within a specific time frame. It is crucial in assessing how a drug is eliminated from the body and has critical clinical applications.
In the one-compartment open model for intravenous (IV) bolus administration, clearance is estimated by dividing the elimination rate by the plasma drug concentration. This equation leverages the elimination rate constant and the apparent...
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One-Compartment Open Model for IV Bolus Administration: General Considerations01:19

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The one-compartment model is a pharmacokinetic tool that models the body as a single, uniform compartment, facilitating the understanding of drug distribution and elimination. This model is particularly beneficial for intravenous (IV) bolus administration, where the drug rapidly circulates throughout the body.
The drug's presence in the body is defined by an equation representing the difference between the rates of drug entry and exit. Key parameters—elimination rate constant,...
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优化和评估基于盒子-Behnken设计的科尔奇辛补丁配方.

Wenliang Dong1,2,3, Jiahao Feng1,2, Xiang Liu1,2

  • 1College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.

AAPS PharmSciTech
|July 8, 2025
PubMed
概括

研究人员使用BOX-Behnken设计 (BBD) 优化了胆固醇 (COL) 透皮贴片,以改善粘附和药物输送. 优化的贴片为口服COL提供了一个有希望的替代品,可能减少副作用.

关键词:
在体外浸透测试中进行透测试.在体外释放测试试验 (in vitro release testing) 进行.盒子背后的实验设计科尔奇辛 (Colchicine) 是一种可怕的药物.通过皮肤贴片的贴片.

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科学领域:

  • 制药科学 制药科学
  • 药物输送系统 药物输送系统
  • 制定 发展 制定 发展

背景情况:

  • 口服胆固醇 (COL) 的使用与胃肠道的副作用有关.
  • 透皮药物递送系统提供了一种潜在的途径,可以绕过第一通代谢并减少全身毒性.
  • 优化通过皮肤贴片的质量属性对于有效的药物输送至关重要.

研究的目的:

  • 为了优化胆固醇 (COL) 通过皮肤贴片,以增强粘附性,药物释放和通过皮肤透.
  • 使用BOX-Behnken设计 (BBD) 开发一种高性能的COL透皮配方.
  • 为了评估优化COL透皮贴片的质量属性和稳定性.

主要方法:

  • 使用BOX-Behnken设计 (BBD) 来优化COL含量,透增强剂 (亚,二醇) 度和溶剂蒸发时间.
  • 为了评估这些变量的影响,进行了17次实验运行.
  • 评估了包括粘附,体外释放 (IVRT) 和透皮透 (IVPT) 在内的质量属性. 还进行了富里埃变换红外光谱 (FT-IR) 和加速稳定性研究.

主要成果:

  • 优化的配方含有9.8%的COL,5%的亚和5%的甘醇,在80°C蒸发23分钟.
  • 优化的贴片表现出良好的粘附性质,并遵循48小时内药物释放和透的韦布尔方程.
  • 获得的累积释放量为27.62mg,累积透量为256.34μg/cm2,没有显著的成分相互作用和良好的稳定性.

结论:

  • BOX-Behnken设计有效优化了COL透皮贴片,产生了一种具有增强质量属性的配方.
  • 开发的透皮系统显示了改善COL输送的潜力,为口服提供了替代品.
  • 优化的COL透皮贴片有望减少与传统口服胆固醇治疗相关的副作用.