衰老会调节血源性骨髓性抑制细胞 (MDSCs) 的免疫抑制,分极和代谢功能

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Emma Keltsch¹, Jennifer Greiner¹, Lena Wahl¹

¹Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Eythst. 24, 89075, Ulm, Germany.

Immunity & ageing : I & A

|July 8, 2025

概括

衰老增加了髓质衍生抑制细胞 (MDSCs),这些细胞损害了T细胞免疫力. 准这些细胞可以促进更健康的衰老,并维持老年人的免疫功能.

科学领域:

免疫学免疫学免疫学
老年学是指老年学的学科.
细胞生物学细胞生物学

背景情况:

免疫衰老,即免疫系统的衰老,增加了对感染和其他与年龄有关的疾病的易感性.
老年人细胞免疫力下降与T细胞和调节细胞的变化有关.
骨髓衍生抑制细胞 (MDSC) 是T细胞功能的关键抑制剂,通常是由慢性炎症引起的.

研究的目的:

分析MDSC诱导和功能的年龄引起的变化.
调查MDSCs对T细胞免疫在衰老中的影响.
为了比较健康的年轻人和老年人的MDSC特征.

主要方法:

在健康的年轻人和老年人中比较MDSC数量和功能.
从外围血液中分离MDSCs,并从CD14+细胞中进行体外生成.
分析MDSC免疫抑制活性,代谢变化以及对T细胞增殖和Th2转移的影响.

主要成果:

年长的成年人表现出显著更高的单细胞 (M-) 和多态核 (PMN-) MDSCs.
来自老年捐赠者的MDSC被更有效地诱导,并显示出增强的T细胞增殖抑制.
老年人中MDSC免疫抑制活性增加与代谢变化和脂质水平升高有关,促进Th2免疫转移.

结论:

免疫发生涉及MDSCs的积累和功能改变,在衰老中损害T细胞免疫力.
MDSCs显著影响与年龄相关的T细胞功能下降.
准MDSC是一种潜在的策略,可以维持T细胞的反应并支持健康的衰老.

关键词:

免疫衰变的起源来自骨髓细胞的抑制细胞.对于T细胞免疫的免疫力.

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