相关实验视频
Updated: Sep 16, 2025

05:10
Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
358
将运动计划纳入阿片类药物激动剂治疗:关于可行性,健身改善和参与挑战的试点研究
Einar Furulund1,2,3,4, Siv-Elin Leirvåg Carlsen5,6, Silvia Eiken Alpers7
1Centre for Alcohol and Drug Research, Stavanger University Hospital, Stavanger, Norway. Einar.furulund@sus.no.
Addiction science & clinical practice
|July 9, 2025
概括
将运动纳入阿片类药物激动剂治疗 (OAT) 表明可行性,并改善有氧健身. 然而,增加的痛苦和疲劳需要进一步的支持和定制的策略来提高OAT计划的低出席率.
科学领域:
- 运动科学 运动科学
- 成 药物 药物 药物 药物
- 公共卫生 公共卫生
背景情况:
- 接受阿片类激素治疗 (OAT) 的人患心血管和精神健康并发症的风险很高.
- 将运动计划纳入OAT可以减轻健康差异,提高整体幸福感.
研究的目的:
- 对接受OAT的个人进行结构化,综合性炼计划的可行性和初步效果进行探索.
- 评估身体健康,心理困扰,疲劳,肺功能和呼吸系统症状的变化.
主要方法:
- 在挪威西部实施了一个为期六周的,以小组为基础的,高强度的耐力和力量训练计划.
- 接受OAT的22名参与者从三个门诊诊所招募.
- 评估包括有氧健身 (4分钟步骤测试),心理困扰 (SCL-10),疲劳 (FSS-3),肺功能和呼吸系统症状,并补充了定性访谈.
主要成果:
- 有氧健身显著改善 (89.4到103.1步循环),尽管28%的出席率.
- 心理困扰 (SCL-10) 和疲劳 (FSS-3) 的分数略有增加.
- 肺功能和呼吸道症状保持稳定;定性数据显示,感知到的好处包括增加自信和社会参与,以及出席方面的挑战.
结论:
- 将运动整合到OAT是可行的,可以提高有氧健身.
- 增加的心理痛苦和疲劳表明需要额外的支持.
- 低出席率凸显了需要量身定制的策略,以提高OAT人群的参与度和优化结果.
相关概念视频
Analgesia and Pain Management
816
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
816
Exercise and Muscle Performance
1.6K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
1.6K
Opioid Receptors: Overview
1.9K
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
1.9K
Opioid Analgesics: Synthetic and Semisynthetic Opioids
438
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
438
Opioid Analgesics: Morphine and Other Natural Cogeners
379
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
379

