在持续贫困地区,结肠直肠癌的生存率差异
Peter DelNero1,2, Mario Schootman1,2, Cheng Peng1,3
1Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
概括
生活在持续贫困地区与非结肠直肠癌 (CRC) 患者的高非结肠直肠癌 (CRC) 死亡率有关. 这些差异在城市环境中更加明显,突出了对癌症存活率的社会经济影响.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 健康的社会经济决定因素
背景情况:
- 持续的贫困是影响健康结果的重要社会经济因素.
- 结肠直肠癌 (CRC) 存活率可能受到各种人口和地理因素的影响.
- 了解癌症存活率的差异对于有针对性的公共卫生干预至关重要.
研究的目的:
- 调查居住在持续贫困人口普查区域和结直肠癌 (CRC) 存活率之间的关联.
- 确定这种关联是否在城市和农村人口之间存在差异.
主要方法:
- 利用全州癌症登记和死亡记录数据从2013年至2019年至2021年.
- 根据管道水平的持续贫困和农村/城市状态,分类CRC患者.
- 使用卡普兰-梅尔估计,日志等级测试,考克斯比例危险和细灰竞争风险模型进行生存分析.
主要成果:
- 长期贫困地区的CRC患者有较高的未调整全因和CRC特定死亡率.
- 经过调整后,持续的贫困仍然与所有原因和非CRC特定死亡率的增加有关,但不是CRC特定死亡率.
- 持续贫困与总体死亡率增加之间的关联在城市地区显著,但在农村地区却没有.
结论:
- 调整后的分析表明,持续贫困地区的CRC患者面临更高的全因和非CRC特异性死亡风险.
- 该研究表明,超出CRC特定原因的因素,如人口统计,地理,瘤特征和治疗,有助于生存差异.
- 可能需要有针对性的干预措施来解决癌症结果的社会经济差异,特别是在城市持续贫困地区.
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