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阴道微生态与高危人乳头瘤病毒 (HR-HPV) 阳性宫皮状内皮病变 (SIL) 之间的相关性分析

Baojin Zeng¹, Xiuling Ren², Yali Cheng²

¹Department of Gynecology, Taizhou Hospital of Zhejiang Province, Linhai City, Zhejiang Province, China.

|July 9, 2025

概括

阴道微生态变化,包括pH值升高和细菌性阴道病 (BV),与高风险的人类乳头瘤病毒 (HR-HPV) 阳性宫平性内皮病变 (SIL) 有关. 乳杆菌的减少和化酶活性的增加是SIL进展的关键预测因素.

科学领域:

妇科妇科医生妇科
微生物学微生物学
在瘤学瘤学.

背景情况:

高风险的人类乳头瘤病毒 (HR-HPV) 感染是宫状皮内皮病变 (SIL) 的主要原因.
阴道微生态在HR-HPV阳性SIL的发展和进展中的作用需要进一步阐明.

研究的目的:

调查阴道微生态与HR-HPV阳性宫SIL之间的相关性.
确定与低级和高级SIL (HSIL) 相关的临床和病毒学因素.

主要方法:

对372名HR-HPV阳性宫病变患者的回顾性分析.
将患者分为三组:内皮层病变或恶性瘤阴性,低度SIL和HSIL.
使用回归分析分析临床因素,HR-HPV类型和阴道微生态参数的分析.

主要成果:

年龄是HSIL的一个重要风险因素 (OR:1.048,P=.026).
特定的HR-HPV类型 (HPV16,HPV18,HPV52) 和多种感染与HSIL相关 (OR:5.810,P=.04).
阴道微生态变化,包括pH值升高 (>4.5),细菌性阴道炎 (BV) 患病率增加 (敏感度为66.10%,HSIL的特异性为70.31%),乳酸菌减少 (OR:3.20,P<.001),并增加了 sialidase 活性 (OR:5.610,P=.002),与HSIL有很强的关联.

结论:

阴道微生态在HR-HPV阳性宫SIL的发展中起着至关重要的作用.
低度SIL和HSIL的关键预测因素包括年龄,HR-HPV类型,阴道pH值升高,微生物密度增加,BV和sianlidase活性.
针对阴道微生态的干预措施可能为管理HR-HPV阳性宫病变提供一种新的方法.

关键词:

高度的状内皮病变.高风险的人类乳头瘤病毒低度的状内皮病变是低度的阴道微生态阴道微生态

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