艾滋病毒感染孕妇的胎儿生长
Dhruv Darji1, Shane Norris2,3, Eric O Ohuma4
1Infectious Disease Epidemiology Unit, Nuffield Department of Population Health.
AIDS (London, England)
|July 9, 2025
概括
对于艾滋病毒感染孕妇 (PWHIV) 的抗逆转录病毒疗法 (ART) 不会影响胎儿的生长,也不会导致婴儿小于妊娠年龄 (SGA). 这支持当前的指导方针,建议PWHIV治疗ART以改善母亲和婴儿的健康.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 胎儿医学 胎儿医学
背景情况:
- 艾滋病毒感染的孕妇 (PWHIV) 面临着分娩婴儿的高风险,这些婴儿对于妊娠年龄 (SGA) 来说很小.
- 了解PWHIV胎儿生长轨迹对于优化产周护理至关重要.
研究的目的:
- 为了比较PWHIV和HIV阴性妇女之间的胎儿生长轨迹.
- 确定母体艾滋病毒感染与子宫内SGA之间的关联.
主要方法:
- 在南非索韦托进行的前性队列研究 (2013-2016).
- 获得了胎儿生物特征和估计胎儿体重 (EFW) 的连续超声波测量.
- 使用多变量线性混合效应模型和逻辑回归来分析增长模式和SGA流行率.
主要成果:
- 在PWHIV和HIV阴性妇女的胎儿之间的平均胎儿生长量或生长速度上没有观察到显著差异.
- 在PWHIV患者中,SGA的患病率从14.2%到26.4%不等,在HIV阴性女性中,SGA的患病率从18.5%到24.1%不等.
- 孕产妇艾滋病毒感染与子宫内SGA或非常SGA (VSGA) 并没有显著关联.
结论:
- 对PWHIV的抗逆转录病毒疗法 (ART) 与胎儿生长,生长速度或子宫内SGA的改变无关.
- 这些发现支持当前的国际指南,建议在PWHIV治疗中使用ART.
- ART有助于改善孕产妇健康和减少垂直艾滋病毒传播.
关键词:
艾滋病病毒 艾滋病病毒 艾滋病病毒腹部周长 腹部周长 腹部周长双对面直径的双对面直径.估计的胎儿体重.腿部长度 腿部长度胎儿的成长 胎儿的成长头部周长 头部周长对于妊娠年龄来说小.超声波超声波是指超声波的使用.更多相关视频
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