吸烟开始作为调解者:通过孟德尔的随机化来调查久坐的生活方式和大麻使用障碍之间的因果关系
Deyu Meng1, Meiqi Wei1,2, Shichun He1,3,4
1Division of Computational Biology, Chinese Center of Exercise Epidemiology, Northeast Normal University, Changchun, China.
Journal of addictive diseases
|July 9, 2025
概括
久坐不动的行为,特别是休时间的屏幕时间,增加了大麻使用障碍 (CUD) 的风险. 然而,久坐不动的工作行为可能有保护作用. 促进体育活动可以通过降低吸烟开始来降低CUD风险.
科学领域:
- 行为遗传学行为遗传学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 大麻使用障碍 (CUD) 的特点是强迫性使用和严重的痛苦.
- 以前的研究表明,大麻使用与减少体力活动或增加久坐行为之间存在联系,但因果关系尚未确立.
- 了解生活方式因素和CUD之间的关系对于制定有效的预防和干预策略至关重要.
研究的目的:
- 使用孟德尔随机化 (MR) 调查身体活动,久坐行为和大麻使用障碍 (CUD) 之间的因果关系.
- 检查吸烟开始在静坐行为和CUD之间的关联中的潜在调解作用.
主要方法:
- 使用孟德尔随机化 (MR) 分析,利用与中度至强度体力活动 (MVPA),休时间屏幕时间 (LST),静坐通勤行为 (SCB) 和工作中静坐行为 (SBW) 相关的遗传变异.
- 吸烟启动的遗传仪器是从大型全基因组关联研究 (GWAS) 中获得的.
- 逆变量加权 (IVW) 方法用于MR分析,敏感性分析包括Cochran的Q测试和MR-Egger回归来评估异质性和性.
主要成果:
- 在工作中久坐不动的行为 (SBW) 证明了对CUD的保护性因果作用 (OR = 0.61).
- 休屏幕时间 (LST) 与CUD风险增加有关 (OR = 1.43).
- 休屏幕时间 (LST) 也因果上增加了吸烟开始的风险 (OR = 1.28),这反过来又与更高的CUD风险有关. 吸烟的开始介导了54.08%的LST相关的CUD风险.
结论:
- 久坐不动的生活方式,特别是大量的休屏幕时间,可能通过吸烟启动的途径导致大麻使用障碍 (CUD).
- 减少久坐不动的行为和鼓励体育活动可能是有效的策略,以降低吸烟开始和随后的大麻相关问题的风险.
- 这些发现强调了生活方式干预在CUD预防和管理中的重要性.
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