健康的植物性饮食与减少炎症性肠病风险有关:一项大规模前性分析
Zhenhe Jin1, Tianyu Zhou1, Kexin Ye1
1Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Molecular nutrition & food research
|July 9, 2025
概括
健康的植物性饮食 (PBD) 可以降低炎症性肠病 (IBD) 的风险. 这项研究发现PBD与IBD相反相关,水果和蔬菜显示有保护作用.
科学领域:
- 营养科学 营养科学
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 观察性研究表明,植物性饮食 (PBD) 可能降低炎症性肠病 (IBD) 风险.
- 需要大规模的前性研究来验证PBD对IBD的保护作用.
- 了解特定的饮食成分和涉及的生物机制至关重要.
研究的目的:
- 评估坚持植物性饮食与发展IBD的风险之间的关联.
- 确定特定的饮食成分,这些成分调解了PBD和IBD之间的关系.
- 探索血清生物标志物的作用,作为这种关联中的潜在调解者.
主要方法:
- 一项前性队列研究,利用英国生物库数据从143,434名参与者.
- 通过24小时回忆来评估饮食摄入量,以计算植物性饮食指数 (PDI).
- 考克斯回归模型用于分析关联;分解和调解分析探讨了饮食和生物标志物的作用.
主要成果:
- 观察到健康的PDI (hPDI) 与性结肠炎 (UC) 和克罗恩病 (CD) 风险之间的不良关联.
- 较高的PBD坚持与降低CD风险有关.
- 增加水果和蔬菜的摄入量显示出保护作用;白细胞,中性粒细胞和C反应蛋白 (CRP) 的升高介导了PBD-IBD关联.
结论:
- 健康的植物性饮食与炎症性肠病的风险相反.
- 植物性食品,特别是水果和蔬菜的抗炎性质可能有助于这种保护作用.
- 与炎症相关的生物标志物,如中性粒细胞,白细胞和CRP,在调解PBD-IBD关系方面发挥着重要作用.
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