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抗胰岛素代谢得分与老年人下肢疼痛之间的关联:一个横截面研究

Yanfen Hu¹, Junxia Yu¹, Zhenjie Xu²

¹Department of Geriatric Endocrinology, Metabolism and Respiratory Medicine (the Cadre Ward), The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Frontiers in endocrinology

|July 9, 2025

概括

胰岛素抵抗 (Mets-IR) 的更高代谢得分与老年人下肢疼痛 (LLP) 风险增加有关. 睡眠时间也在这种关联中发挥作用,这表明了潜在的干预措施.

科学领域:

老年学是一门学科.
代谢健康代谢健康
疼痛管理疼痛管理

背景情况:

胰岛素抵抗在老年人群中是一个越来越令人担忧的问题.
下肢疼痛 (LLP) 显著影响老年人的生活质量.
代谢功能障碍和慢性疼痛之间的关系需要进一步调查.

研究的目的:

为了检查胰岛素抵抗 (Mets-IR) 和下肢疼痛 (LLP) 的代谢得分在老年人队列中的关联.
探索这种关系中的潜在调解或调节因素,例如睡眠时间.

主要方法:

利用来自中国健康与退休长度研究 (CHARLS) (2011年和2018年) 的基线和后续数据.
使用多变量物流回归和受限立方线分析来评估Mets-IR和LLP协会.
进行了子组和相互作用分析,以调查睡眠时间的影响.

主要成果:

总共有4983名老年参与者被分析,其中67.2%报告LLP.
后勤回归证实了较高的Mets-IR和LLP风险增加之间的显著正相关性 (p < 0.001).
限制性立方脊线分析表明存在非线性关系,睡眠时间成为一个重要的相互作用因素.

结论:

该研究表明,胰岛素抵抗的代谢得分与老年人下肢疼痛风险之间存在明显的正相关性.
睡眠时间对Mets-IR和LLP之间的关联产生了相互影响,这突显了它在管理这一群体的疼痛方面的重要性.

关键词:

跨截面研究是跨截面研究.胰岛素耐药性是一种胰岛素耐药性.下肢疼痛下肢疼痛的情况胰岛素抵抗的代谢评分代谢综合征代谢综合征

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