怀孕期间母亲的食铁摄入量对新生儿肠道微生物群概况有潜在的影响
Qi Qi1, Danmeng Liu2, Liang Wang1
1Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Frontiers in nutrition
|July 9, 2025
概括
怀孕期间母亲的铁摄入量对婴儿肠道微生物群的多样性产生积极影响. 母亲的铁消耗较高与新生儿的有益细菌增加有关,特别是在阴道分娩后.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 孕产妇和胎儿的健康
背景情况:
- 铁是怀孕的关键营养素,影响胎儿的发育.
- 母亲肠道微生物群 (GM) 的组成可以影响新生儿发育的GM.
- 怀孕期间饮食中铁的摄入量是塑造早期生命的潜在因素GM.
研究的目的:
- 研究孕妇在怀孕期间饮食中摄入的铁和母亲和新生儿的肠道微生物群 (GM) 之间的联系.
- 为了确定母亲的铁消费是否影响新生儿肠道微生物多样性和组成.
主要方法:
- 分析了95个母亲-新生儿二合体.
- 使用食物频率问卷 (FFQ) 评估母亲的饮食铁摄入量.
- 16S rRNA amplicon测序用于表征母体 (第三个三个月) 和新生儿便样本.
主要成果:
- 新生儿肠道微生物群的多样性在铁摄入量较高的母亲的婴儿中明显更大 (香农p = 0.04;辛普森p = 0.01).
- 这种增加的多样性特别在通过正常阴道分娩 (NVD) 出生的婴儿中被注意到.
- 母亲的饮食铁摄入量解释了新生儿转基因成分变化的10.24% (p = 0.007).
结论:
- 孕妇在怀孕期间摄取足够的食铁,可能会促进新生儿的有益细菌殖民.
- 更高的铁消耗可能会增强新生儿肠道微生物群的生物多样性.
- 这凸显了母亲营养对婴儿肠道健康的重要性.
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