体重不足与潜伏结核病感染的成年人死亡率增加有关
Jun-Zhe Liao1, Xiao Liu1, Min Qi2
1Department of Respiratory and Critical Care Medicine, Chengdu Fifth People's Hospital, Chengdu, China.
Frontiers in nutrition
|July 9, 2025
概括
患有潜伏结核病感染的体重不足的人面临更高的死亡风险. 体重指数显示出与死亡率的U形关系,最佳生存率在BMI为27.3kg/m2时.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 传染性疾病 传染性疾病
背景情况:
- 潜伏性结核病感染 (LTBI) 作为活动性结核病 (TB) 的储存库.
- 身体质量指数 (BMI) 影响LTBI进展和活跃结核病的结果.
- 在LTBI患者中,BMI与死亡风险之间的关联需要进一步调查.
研究的目的:
- 为了研究BMI和死亡率之间的关系,在美国的一组LTBI患者中.
- 确定BMI是否是LTBI患者死亡率的独立预测因素.
主要方法:
- 利用了2011-2012年国家健康和营养检查调查 (NHANES) 的数据.
- 采用卡普兰-梅尔曲线和多变量考克斯回归来评估BMI类别之间的生存差异.
- 应用限制立方斜线 (RCS) 分析以建模非线性BMI与死亡率的关系.
主要成果:
- 体重不足的LTBI参与者 (BMI <18.5 kg/m2) 的死亡风险明显更高 (调整HR=2.77,p=0.04).
- 在超重或肥胖的LTBI参与者中没有发现显著的死亡相关性.
- RCS分析显示了一个U形的BMI-死亡率曲线,表明BMI为27.3kg/m2的最低死亡风险 (p为非线性=0.0012).
结论:
- 体重不足状态是LTBI成年人死亡率增加的独立预测因素.
- 超重或肥胖似乎与该LTBI队列的死亡率增加无关.
- 在BMI和LTBI中死亡率之间存在U形关系,在BMI为27.3kg/m2时观察到最佳生存率.
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