肠道微生物组作为未来CKD的风险因素
Tapio Hellman1, Li-Fang Yeo2,3, Joonatan Palmu2,3,4
1Kidney Center, Turku University Hospital and University of Turku, Turku, Finland.
Kidney international reports
|July 9, 2025
概括
下肠道微生物多样性与患慢性病 (CKD) 的风险增加有关. 这项研究表明,Lachnospiraceae家族在维持脏健康方面可能发挥作用.
科学领域:
- 微生物组研究的研究.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 公共卫生 公共卫生
背景情况:
- 小规模研究表明,肠道微生物群与慢性病 (CKD) 有关.
- 肠道微生物组组成和发生的CKD之间的长期关系尚未得到充分证实.
研究的目的:
- 调查基线肠道微生物组与长期发生的CKD之间的关联.
- 探索肠道元基因组,血清肌素 (SCR) 和尿液白蛋白与肌素比率 (UACR) 之间的联系.
主要方法:
- 在基于人口的队列中取便样本并测量SCR和UACR (SCR为N=6699,UACR为N=797).
- 评估肠道元基因组与基线SCR,UACR和事件CKD之间的多变量调整的关联,在18.6年的中位数随访期间.
主要成果:
- 肠道微生物群α多样性的增加与发生CKD的风险较低有关 (HR每1SD:0.84;P=0.04).
- 阿尔法和β多样性与基线SCR相关,但不是UACR.
- 发现了43个物种级别与SCR的关联,包括与Lachnospiraceae家族成员的负面关联.
结论:
- 肠道微生物多样性减少可能预测未来的CKD风险.
- 拉克诺斯皮拉家族与脏健康之间存在潜在的联系,需要进一步调查.
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