移植后复发性狼性炎的临床病理特征使用监测和指示活检
Maria Lourdes Gonzalez Suarez1, Wen Jiqiu2, Andrea G Kattah1
1Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.
Kidney international reports
|July 9, 2025
概括
移植 (KTx) 后的复发性狼性炎 (RLN) 是常见的,影响35.7%的患者. 通过监视活检进行早期诊断对于管理这种情况和预防移植损失至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植免疫学 移植免疫学
- 病理学 病理学 病理学
背景情况:
- 移植 (KTx) 后复发性狼性炎 (RLN) 的发生率是可变的.
- 监测活检显示RLN率高于临床指示活检.
研究的目的:
- 评估KTx接受者与原生狼病的RLN的发病率和病理学.
- 评估监视活检在早期RLN检测中的有用性.
主要方法:
- 在209名首次KTx接受者中进行了多站点的回顾性研究,他们患有先天性狼病.
- 对RLN检测和表征的监测和临床指示活检的分析.
主要成果:
- 在有足够活检材料的35.7% (40/112) 患者中观察到RLN.
- 描述了组织学RLN (HRLN) 和临床RLN (CRLN);非洲裔美国人的复发率最高 (48.3%).
- 中血管增殖模式 (ISN/RPS Class II LN) 是最常见的;在50%的RLN患者中发生了移植损失.
结论:
- 在KTx之后RLN很常见,并且可以在临床上保持沉默.
- 序列活检评估有助于了解RLN的自然史,并促进早期诊断.
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