不同霍奇金淋巴瘤类型的长期幸存者中心血管疾病死亡风险
Zhenxing Lu1, Liyu Guo2,3, Huijuan He2,3
1Department of Cardiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 330006 Nanchang, Jiangxi, China.
Reviews in cardiovascular medicine
|July 9, 2025
概括
随着时间的推移,大多数幸存者的心血管疾病 (CVD) 死亡风险超过了霍奇金淋巴瘤 (HL) 死亡风险. 风险因HL亚型而异,需要定制策略来长期降低心血管疾病风险.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 心血管疾病 (CVD) 死亡率趋势和霍奇金淋巴瘤 (HL) 幸存者的差异尚不清楚.
- 研究这些趋势对于改善患者长期治疗结果至关重要.
研究的目的:
- 检查不同霍奇金淋巴瘤 (HL) 亚型的幸存者中心血管疾病死亡风险的时间趋势.
- 根据HL亚型和患者人口统计数据,识别心血管疾病死亡风险的差异.
主要方法:
- 一项多中心队列研究包括20423名在1975年至2018年期间被诊断为HL的HL患者.
- 随访时间平均为18.5年,分析包括比例死亡率和累积因特定原因死亡率.
- 计算了标准化死亡率和绝对超额风险,以评估心血管疾病死亡率.
主要成果:
- 结节性淋巴细胞主导性HL (NLPHL) 的死亡超过了HL的死亡,大约在12个月后,古典HL的死亡超过了120个月.
- 累积心血管疾病死亡率持续上升,在大多数HL亚型的不同时间点超过HL死亡率.
- 特定的HL亚型和人口统计因素 (如种族,性别) 与差异性心血管疾病死亡风险有关.
结论:
- 在许多长期幸存者中,心血管疾病死亡风险最终超过HL死亡风险,HL亚型之间存在显著差异.
- 心血管疾病死亡率的时间趋势在HL亚型之间存在很大差异,这凸显了对亚型特定管理的需要.
- 制定有针对性的策略以减轻心血管疾病死亡风险对于改善霍奇金淋巴瘤幸存者的长期健康至关重要.
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