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失控糖尿病对心肌的全球纵向应变的影响:一个病例对照研究
Khaled Elenizi1, Rasha Alharthi2, Abdullah Alanazi3
1Department of Internal Medicine, College of Medicine, Prince Sattam bin Abdulaziz University, 11942 Alkharj, Saudi Arabia.
Reviews in cardiovascular medicine
|July 9, 2025
概括
失控的糖尿病及其并发症显著损害左心室全球纵向应变 (GLS),表明早期的心脏功能障碍. 监测GLS对于在糖尿病患者中检测心脏问题至关重要.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 医疗成像医学成像
背景情况:
- 糖尿病微血管病对左心室 (LV) 功能的影响尚未完全理解.
- 心肌张力成像检测到LV静脉缩功能障碍早于喷射分数.
- 这项研究调查了不受控制的糖尿病和受损的LV全球纵向菌株 (GLS) 之间的联系.
研究的目的:
- 评估未控制的2型糖尿病 (DM) 与减少的LV全球纵向菌株 (GLS) 之间的关系.
- 为了比较GLS在不受控制的DM患者与健康个体.
- 评估糖尿病微血管并发症对GLS的影响.
主要方法:
- 在76名无症状患者中进行过胸腔心声扫描,其中76名是无控制的2型糖尿病患者和76名匹配的对照人群.
- 排除标准包括冠状动脉疾病,低LV喷射率 (<55%),心房动或低回声质量.
- 糖尿病的微血管并发症包括视网膜病变,小白蛋白尿,病或神经病变.
主要成果:
- 绝对GLS%在糖尿病组 (-18.4 ± 1.7) 与对照组 (-22 ± 1.9,p < 0.001) 相比显著较低.
- 患有微血管并发症的糖尿病患者呈现逐渐较低的绝对GLS%值.
- 回归分析显示,并发症数量与绝对GLS%的减少之间存在正相关性 (β = 0.41,p < 0.001).
结论:
- 失控的糖尿病及其并发症与心肌变形受损有关,以较低的绝对GLS%为证据.
- GLS%是糖尿病患者心脏参与的潜在早期标志物.
- 这些发现强调了在糖尿病人群中进行GLS监测的必要性.
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