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基因与环境的相互作用有助于全球人口的血压变化
Khushi Goda1,2, Noah Klimkowski Arango1,2, Francesco Tiezzi1,3
1Center for Human Genetics, Clemson University, Greenwood, SC, USA.
medRxiv : the preprint server for health sciences
|July 9, 2025
概括
基因与环境的相互作用显著解释了不同人群中更多的血压 (BP) 变化. 这凸显了多祖先队伍对于理解复杂特征的重要性.
科学领域:
- 遗传学 遗传学 是一个
- 环境健康 环境健康
- 心血管疾病研究研究
背景情况:
- 了解遗传和环境对血压 (BP) 等复杂特征的影响至关重要.
- 众所周知,基因与环境相互作用 (G×E) 影响BP,但它们在多祖先队列中的作用未得到充分研究.
研究的目的:
- 评估G×E对缩 (SP),腹缩 (DP) 和脉冲压 (PP) 变化的贡献,在一个多样化的英国生物库队列中.
- 为了比较G×E效应在一个多祖先的群体与一个只有英国白人群体.
主要方法:
- 分析了来自英国生物库的25,000个不同祖先的个体.
- 评估23个生活方式变量作为环境暴露.
- 对人口统计,人口结构,遗传学,环境和G×E的方差组件的估计.
主要成果:
- G×E解释了DP变异的7%,SP变异的4%,PP变异的3%.
- 这些G×E贡献高于之前在英国白人的英国生物银行分析中报告的 (2%用于所有BP特征).
- G×E-全基因组协会研究 (GWAS) 确定了BP相关途径中的暗示性相互作用和丰富基因,尽管没有一个达到全基因组意义.
结论:
- 多祖先队伍中的环境和遗传异质性放大了G×E对血压的影响.
- 多样化的种群对于充分捕捉复杂特征的遗传结构至关重要.
- 虽然G×E在交叉验证中没有提高预测准确性,但它在解释差异方面的作用在不同组中很重要.
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