特定的炎症刺激会激活先天免疫传感器,从而诱导巨细胞中的新型CD103表达特征
Nasry Zane Bouzeineddine1, Sebastien Talbot1, Sam Basta1
1Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.
Frontiers in cellular and infection microbiology
|July 9, 2025
概括
在特定的炎症条件下,巨细胞可以表达通常在T细胞和树突细胞上发现的整合素CD103. 这一发现扩大了CD103在免疫细胞调节中的已知作用.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
背景情况:
- 集成蛋白CD103对于在上皮组织中的免疫细胞粘附至关重要.
- CD103是已知的CD8+T细胞和常规1型树突细胞 (cDC1) 的标记物.
- 在巨细胞上CD103表达的理解很差.
研究的目的:
- 在炎症条件下研究巨细胞中CD103表达.
- 要确定巨分化因子 (M-CSF,GM-CSF) 是否影响CD103的表达.
- 探索调节巨细胞中CD103的信号通路.
主要方法:
- 使用M-CSF或GM-CSF的骨髓衍生分化的巨细胞 (BMDMs).
- 刺激的BMDMs与病原体相关的分子模式 (PAMPs) 和病毒感染.
- 评估了CD103表达,并使用了p38 MAPK抑制.
- 在in vivoLCMV感染后检查的腹巨细胞.
主要成果:
- 在基线时CD103表达是最小的,但在M-CSF分化的巨细胞中通过内体的TLR激动剂刺激后上调.
- p38 MAPK信号通路参与CD103的上调.
- 在体内,LCMV感染诱导了CD103表达在腹膜巨细胞上.
结论:
- 巨细胞可以在特定的炎症刺激下表达CD103.
- 这挑战了CD103作为T细胞和树突细胞独有的既定观点.
- 提供了对巨细胞生物学和CD103调节的新见解.
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