在患有上胃肠腺瘤的患者中遵循您的"肠道"呼叫进行结肠镜检查:系统性审查和元分析
Hanyuan Xu1, Kai Song2, Yuelun Zhang3
1Department of Clinical Nutrition, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
患有上部胃肠道 (UGI) 腺瘤的患者患有结直肠腺瘤和结直肠癌 (CRC) 的风险明显更高. 这一元分析支持对被诊断患有UGI腺瘤的个人进行结肠镜查的必要性.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 预防医学 预防医学
背景情况:
- 通过结肠镜检查早期发现腺瘤可以降低结肠直肠癌 (CRC) 的发病率和死亡率.
- 在患有上部胃肠道 (UGI) 腺瘤的患者中评估结肠镜的必要性的证据有限.
研究的目的:
- 评估UGI腺瘤患者结直肠瘤的风险.
- 提供基于证据的建议,关于UGI腺瘤患者是否应该接受结肠镜检查.
主要方法:
- 系统性审查和对比结肠直肠瘤风险的研究的元分析在患有和没有UGI腺瘤的患者中.
- 搜索了PubMed和Embase数据库,截至2024年11月30日.
- 使用随机效应模型估计了聚合概率比率 (ORs),并使用试验序列分析 (TSA) 来控制错误.
主要成果:
- 与210,508名参与者进行的15项研究显示,UGI腺瘤和结直肠腺瘤风险增加之间存在显著联系 (OR2.36).
- 十二指甲腺瘤与晚期结直肠腺瘤 (OR 2.95) 和CRC (OR 2.15) 的更高风险相关.
- 亚组分析表明,胃腺瘤和十二指腺瘤都会增加结直肠腺瘤的风险.
结论:
- 这一元分析是第一个在患有UGI腺瘤的患者中显示结直肠腺瘤和CRC的风险增加的分析.
- 这些发现强调了结肠镜对于UGI腺瘤患者的重要性.
- 结果补充了现有的结肠镜查指南.
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