在西班牙的移植候选人中,虚弱的流行和特征:一个多中心研究
María José Pérez-Sáez1,2, Edoardo Melilli3, Marta Arias4
1Nephrology Department, Hospital del Mar, RICORS2040 RD21/0005/0022, Barcelona, Spain.
概括
在西班牙,近一半的脏移植候选人是先前脆弱或脆弱的. 脆弱性在女性和那些有重大健康问题的人群中更为常见,需要早期识别和干预.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 老年病的医生 老年病的医生
- 公共卫生 公共卫生
背景情况:
- 脆弱性是移植候选人 (KTc) 的不良结果的重要预测因素.
- 了解脆弱性患病率对于优化移植前护理和移植后结果至关重要.
研究的目的:
- 为了确定一个代表性的西班牙KTc人群中的脆弱性和脆弱性前期的患病率.
- 为了确定与这个队列中的脆弱性相关的人口和临床因素.
主要方法:
- 一项多中心,横截面研究,涉及1194名50岁及以上的KTc.
- 使用经过验证的FRAIL尺度进行脆弱性评估.
- 统计分析包括多变量后勤回归来确定相关因素.
主要成果:
- 8.2%的KTc被归类为脆弱,41.5%为脆弱前,总计近50%受影响.
- 脆弱性在女性 (OR 3.9) 患者,伴随性疾病负担较高的患者 (CCI >6,OR 2.9) 和服用更多药物的患者 (OR 1.13/药物) 中明显更为普遍.
- 在女性,血液透析患者和高查尔森并发症指数 (CCI) 患者中观察到更高的患病率.
结论:
- 几乎一半的西班牙KTc是脆弱或脆弱的,突出了相当大的风险人口.
- 脆弱性独立地与女性性别,高并发症负担和多药性有关.
- 早期识别KTc的脆弱性对于风险分层和制定有针对性的干预措施来改善移植结果至关重要.
更多相关视频
05:53Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
16.7K
09:00TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients
Published on: April 13, 2021
4.7K
相关概念视频
01:28Kidney Transplant I: Introduction
64
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
64
01:16Kidney Transplant III: Nursing Management
84
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
84
01:26Kidney Transplant II: Surgical Procedure
78
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
78
01:24Chronic Kidney Disease II: Clinical Manifestations
104
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
104
01:25Chronic Kidney Disease I: Introduction
76
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
76
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
59
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
59