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Updated: Sep 16, 2025

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ti-scMR:基于轨迹推理的动态单细胞门德尔随机化确定了表型差异背后的因果基因

Jianle Sun1,2, Qun Dong1, Jialu Wei1

  • 1Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.

NAR genomics and bioinformatics
|July 9, 2025
PubMed
概括

我们开发了基于轨迹推断的动态单细胞孟德尔随机化 (ti-scMR) 来发现因果基因,将基因型与表型联系起来. 这种方法整合了单细胞数据和遗传变异,以确定影响细胞发育和疾病的基因.

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