低收入和中等收入国家新生儿侵入性角膜炎的负担:系统性审查和元分析
Daniel Hsiang-Te Tsai1,2, Ian Chang-Yen Wu1,2,3, Ling-Fang Chang4,5
1Centre for Neonatal and Paediatric Infection, City St. George's, University of London, London, UK.
Open forum infectious diseases
|July 9, 2025
概括
新生儿侵袭性角膜炎 (NIC) 是低收入和中等收入国家 (LMICs) 的一个主要威胁,发病率为2.6%,死亡率为18.7%. 流可纳耐药性是一个日益关注的问题,需要针对性预防和治疗策略的NIC在LMICs.
科学领域:
- 新生儿科学 新生儿科学
- 传染性疾病 传染性疾病
- 全球健康 全球健康
背景情况:
- 侵入性Candida感染对新生儿构成重大全球威胁.
- 关于新生儿入侵性候群病 (NIC) 在低收入和中等收入国家 (LMICs) 的负担和特征的数据有限.
研究的目的:
- 调查LMIC中NIC的发病率,病例死亡率 (CFR),流行病学和病因学.
- 解决资源有限的环境中关于NIC的知识差距.
主要方法:
- 进行了系统的文献综述和元分析.
- 分析了来自257篇文章的数据,这些文章涉及27个LMIC的微生物学确认的NIC病例.
主要成果:
- 总体NIC发病率为2.6%,东南亚地区的发病率最高 (6.3%).
- 虫 (39.0%) 和虫 (24.8%) 是主要的物种.
- 很大一部分 (24.8%) 的隔离物表现出可纳耐药性,聚合的CFR为18.7%.
结论:
- 与高收入国家相比,NIC发病率和CFR在LMIC中更高.
- 具有NIC的LMIC中的新生儿早产率较低,出生体重较高.
- 针对NIC的有针对性的预防和治疗策略对于LMIC环境至关重要,这是由于高可纳耐药性.
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