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Updated: Sep 16, 2025

Chemical Dimerization-Induced Protein Condensates on Telomeres
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过渡的多 (ADP-Ribose) 触发了FUS凝结歇斯底里通过一种类似于的机制

Hongrui Liu1,2, Yuxuan Cai1, Leilei Shi3

  • 1Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

bioRxiv : the preprint server for biology
|July 9, 2025
PubMed
概括

聚ADP-ribose (PAR) 结合诱导了Fused in Sarcoma (FUS) 蛋白质的形状变化,使得细胞内持续凝结. 这种机制解释了FUS凝结物如何在初始PAR信号发送后持续存在,模仿像子一样的行为.

关键词:
的DNA修复焦点.在瘤中融化 (FUS)聚ADP-糖 (PAR) 是一种多ADP-糖.生物分子凝聚剂的生物分子凝聚剂类域 (PrLD) 是一种类似子的域.

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