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Updated: Sep 16, 2025

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瘤细胞中的IFN I反应是由PARP7-p300/CBP相互作用通过明显的功能丧失和功能获取机制形成的

Ivan Rodriguez Siordia, Sonja Rieth, Rory Morgan

    bioRxiv : the preprint server for biology
    |July 9, 2025
    PubMed
    概括

    聚 (ADP-ribose) 聚合酶7 (PARP7) 通过修改共激活剂p300和CBP来调节I型干扰素 (IFN-β). PARP7 抑制剂通过双重机制诱导 IFN-β,包括功能丧失和功能增益效应.

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