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Updated: Sep 16, 2025

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小鼠肠道微生物群对捕食者的气味做出反应,并预测宿主行为的行为
Madalena V F Real1,2, Maren N Vitousek1, Michael J Sheehan3
1Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY 14853, USA.
bioRxiv : the preprint server for biology
|July 9, 2025
概括
暴露于急性捕食者气味显著改变了小鼠肠道微生物群,影响了宿主行为和基因表达. 这些微生物变化预测了行为反应,突出了肠道微生物组在急性压力反应中的作用.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 动物行为 动物行为
背景情况:
- 慢性压力会影响哺乳动物的肠道微生物,影响宿主反应.
- 急性压力因素对肠道微生物群的影响及其与宿主应激反应的相互作用不太清楚.
研究的目的:
- 为了研究急性捕食者气味暴露对肠道微生物群和野生来源小鼠宿主压力反应的影响.
- 确定急性压力因素如何与慢性压力模式 (如社会隔离) 相互作用.
主要方法:
- 实验性暴露小鼠合成狐气味和社会隔离.
- 行为测试,内脏脂肪组织转录组学和元基因组组装基因组 (MAG) 分析.
- 随机森林分类,以从肠道微生物组成中预测宿主行为.
主要成果:
- 短暂的捕食者气味暴露对肠道微生物群和基因表达产生了更大的影响,而不是长时间的社会隔离.
- 捕食者嗅觉敏感细菌的丰富性预测了宿主理,社会行为和抗微生物防御基因表达.
- 肠道微生物群的组成显著预测了治疗组内的行为变化.
结论:
- 暴露于急性捕食者气味会改变野生来源小鼠的肠道微生物群落.
- 肠道微生物群在调解宿主对急性,生态相关的压力因素 (如掠食威胁) 的反应方面发挥着重要作用.
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