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Updated: Sep 16, 2025

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探索MBD2蛋白质对甲基化CpGDNA识别的双稳平衡

Senta Volkenandt1, Julia Belyaeva2, Torry Li3

  • 1Computer Chemistry Center, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Nägelsbachstrasse 25, 91052 Erlangen, Germany.

bioRxiv : the preprint server for biology
|July 9, 2025
PubMed
概括

甲基-CpG结合域2 (MBD2) 对甲基化CpG表现出双稳定结合,形成两个不同的状态. 一个关键的残留物S189作为一个开关,影响结合亲和力和 conformational 动态.

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