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Updated: Sep 16, 2025

In Vitro Analysis of E3 Ubiquitin Ligase Function
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In Vitro Analysis of E3 Ubiquitin Ligase Function

Published on: May 14, 2021

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由UBQLN2招募E3酶可以保护基质免受蛋白质体降解

Ashley N Scheutzow, Sachini Thanthirige, Gracie Siffer

    bioRxiv : the preprint server for biology
    |July 9, 2025
    PubMed
    概括

    尤比基林,特别是UBQLN2,通过形成相分离凝聚物,独特地保护蛋白质免受降解,ALS突变的功能受损,揭示了神经退行性疾病的新范式.

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