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Updated: Sep 16, 2025

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay
09:03

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay

Published on: March 10, 2020

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β-逮捕素的招募促进了与G蛋白的直接关联

Claudia Y Lee1,2, Jeffrey S Smith3,4, Taylor Kohlmann2,5

  • 1Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA.

bioRxiv : the preprint server for biology
|July 9, 2025
PubMed
概括

G蛋白结合受体 (GPCRs) 通过G蛋白和β-arrestin发出信号. 这项研究揭示了G蛋白和β-arrestin之间的直接相互作用,澄清了它们在GPCR信号通路中的综合作用.

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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators07:41

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