整个大脑的血液体积反映了相反的神经群体
Agnès Landemard1, Michael Krumin1, Kenneth D Harris2
1UCL Institute of Ophthalmology, University College London.
bioRxiv : the preprint server for biology
|July 9, 2025
概括
大脑的血液供应与神经活动有关,但这项研究揭示了两个不同的神经群体,其作用相反. 它们的联合活动更好地预测了老鼠大脑中血液体积的变化.
科学领域:
- 神经科学是一个神经科学.
- 身体生理学 身体生理学
背景情况:
- 传统上,大脑的血液供应与整体的神经活动有关.
- 之前的研究使用了批量测量,限制了对区域和依赖兴奋的差异的理解.
研究的目的:
- 为了研究神经元活动和血液体积波动在老鼠大脑之间的关系.
- 为了确定不同神经群体如何对大脑范围的血液供应调节作出贡献.
主要方法:
- 同时功能性超声成像 (fUSI) 和神经像素记录在小鼠中.
- 测量神经元活动和与特定事件相关的血液体积变化,如鞭打 (兴奋的标志物).
主要成果:
- 神经元活动和血液体积波动在大脑区域之间始终相关.
- 确定了两个具有相反活动模式的不同神经群体.
- 这些群体表现出不同的血液动力学反应功能,并且存在于整个大脑.
- 这些群体的综合活动准确地预测了血液体积的变化,超过了批量神经活动措施.
结论:
- 鼠标大脑包含两个对立的神经群体,调节血液供应.
- 这些与兴奋状态相关的群体,共同解释了整个大脑的血液体积波动.
更多相关视频
07:57Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin
Published on: August 25, 2022
3.1K
08:32Neurovascular Network Explorer 2.0: A Simple Tool for Exploring and Sharing a Database of Optogenetically-evoked Vasomotion in Mouse Cortex In Vivo
Published on: May 4, 2018
6.5K
相关概念视频
Neural Regulation of Blood Pressure
3.5K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
3.5K
The Blood-brain Barrier
48.9K
Overview
48.9K
Anatomy of the Brain: Ventricles
5.2K
There are hollow fluid-filled cavities known as ventricles deep inside the human brain. There are two lateral ventricles, one in each cerebral hemisphere, and each has three different projections — the anterior, inferior, and posterior horns visible from the lateral side. A thin membrane called the septum pellucidum separates the two lateral ventricles. The slender third ventricle in the diencephalon is connected to each lateral ventricle via a channel called the interventricular foramen.
5.2K
Veins as Blood Reservoirs
6.5K
Veins, while chiefly responsible for circulating blood back to the heart, also function as storage vessels for blood. They house approximately 64 percent of the body's total blood volume, a feat made possible by their high capacitance—the inherent ability to expand and accommodate large volumes of blood, even under low pressure. The large diameter and thin walls of veins augment their distensibility, significantly more so than arteries, due to their classification as capacitance...
6.5K
Cerebral Hemispheres
559
The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
559
Magnetic Resonance Imaging
7.2K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
7.2K
