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认知行为疗法和lisdexamfetamine,单独和组合,用于过度饮食障碍:随机对照试验的二次结果
Carlos M Grilo1, Valentina Ivezaj1, Sydney Yurkow1
1Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA.
The International journal of eating disorders
|July 9, 2025
概括
认知行为疗法 (CBT) 和利斯美胺 (LDX),特别是结合使用,显著改善了暴饮暴食障碍 (BED) 的结果. 这些治疗也积极影响了行为,心理和代谢因素,而不仅仅是减少过度饮食.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 暴饮暴食障碍 (BED) 是一种具有复杂的行为和代谢组成部分的重大心理健康状况.
- 现有的BED治疗方法包括心理治疗和药物治疗,但它们的比较有效性和对二次结果的影响需要进一步研究.
研究的目的:
- 评估认知行为疗法 (CBT),利斯美胺 (LDX) 和它们的组合对BED患者的二次结局的影响.
- 通过检查行为,心理和代谢变量来扩大对BED治疗的理解.
主要方法:
- 一个为期12周的随机对照试验 (RCT) 涉及141名患有BED的患者.
- 患者被随机分为三个组:CBT,LDX或结合CBT + LDX.
- 87.2%的参与者完成了治疗后的评估.
主要成果:
- 所有治疗都导致了与饮食相关的变量 (食欲,快乐欲望) 和代谢因素 (胆固醇,甘油三) 的显著减少.
- 结合CBT + LDX治疗显示出最大的减少,并且表现优于单个治疗.
- 对形状/体重和冲动性的高估在所有组都显著下降,但在治疗之间没有差异.
结论:
- CBT和LDX,特别是在组合中,对BED治疗的次要结果产生广泛的积极影响.
- 这些发现表明,组合疗法提供了优势,超出了它对暴饮暴食的主要影响.
- 未来的研究应该探索BED中治疗反应的调节者和调解者.
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