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治疗性肝切除后肝细胞癌复发的性别差异:一个多中心综合分析
Mu-Gen Dai1, Si-Yu Liu2, Qing Xu3
1Department of Gastroenterology.
European journal of gastroenterology & hepatology
|July 9, 2025
概括
男性在手术后面临的肝细胞癌 (HCC) 复发风险比女性更高. 性别影响复发时间和风险,男性经历更早和更高的峰值复发率.
科学领域:
- 肝胆道手术是肝胆道的手术.
- 手术瘤学手术瘤学
- 癌症复发研究 癌症复发研究
背景情况:
- 治疗切除后肝细胞癌 (HCC) 复发的性别差异尚不清楚.
- 对HCC复发模式的性别差异的调查对于个性化治疗策略至关重要.
研究的目的:
- 综合分析性别对治疗性肝切除术后HCC复发的影响.
- 为了确定性别是否是早期或晚期HCC复发的独立风险因素.
主要方法:
- 从一个多中心数据库 (从2015年7月至2020年6月) 来回顾1570名接受治疗意图的HCC切除的患者的回顾性分析.
- 使用多变量考克斯回归,卡普兰-梅尔方法和里程碑分析评估瘤复发.
- 敏感性分析包括倾向性得分匹配和竞争性风险模型.
主要成果:
- 与男性相比,女性患者的HCC复发风险明显较低 (HR:0.75,P=0.008).
- 性是晚期复发的独立预测因素,但不是早期复发.
- 男性患者的高峰复发率和较早的复发时间 (高峰在3.0个月) 比女性更高.
结论:
- 男性性与肝切除术后HCC复发风险增加有关.
- 性别之间复发危险率存在显著差异,受时间和高峰率的影响.
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