转移性膀癌的转移切除术的有效性:系统性审查和元分析

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Junjie Ji^1,2,3, Fengju Guan¹, Lijiang Sun¹

¹Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, China.

International journal of urology : official journal of the Japanese Urological Association

|July 9, 2025

概括

转移切除术改善了转移性膀癌 (BCa) 患者的生存率. 这种手术方法对脑转移患者尤为有益,提供一种潜在的治愈选择.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
在瘤学瘤学.
手术瘤学手术瘤学

背景情况:

转移切除术被提议作为单次转移的治疗方法.
转移性膀癌 (BCa) 中转移切除术的作用需要澄清.

研究的目的:

系统地审查和元分析转移切除术在膀癌中各种转移部位的疗效.
澄清转移切除术对转移性膀癌患者整体生存期的作用和影响.

主要方法:

来自PubMed,Embase和Cochrane图书馆的英语文章的系统审查 (发布至2025年6月7日).
提取研究特征,生存数据和95%置信区间 (CI) 的危险比率 (HR).
使用PRISMA指南和纽卡斯尔-太华尺度进行质量评估,对整体生存 (OS) 的元分析.

主要成果:

8篇文章 (15,139名患者) 符合纳入标准,发表于1992年至2024年之间.
与非手术治疗相比,转移切除与明显更好的整体存活率 (OS) 相关 (HR=0.46,95% CI 0.27-0.79).
在患有脑转移的患者中观察到OS和转移切除术之间的积极关联 (HR=0.49,95% CI 0.34-0.70).

结论:

转移切除术与转移性膀癌 (BCa) 患者的生存状况改善有关.
这种益处在患有脑转移的患者中尤为明显.
转移切除术应被认为是可行的和适当的治疗选择BCa,当有指示时.

关键词:

转移性切除术 (metastasectomy) 是一种转移性切除术.转移的膀癌转移的膀癌这是一个元分析.预后预后预后

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