脑下垂体体积与自闭症和非自闭症幼儿的睡眠失调有关
Burt Hatch1,2, Derek Sayre Andrews1, Brett Dufour1
1University of California, Davis, USA.
概括
右下丘脑体积较小与自闭症和非自闭症儿童的睡眠问题有关. 外向化的行为部分解释了这种关联,突出显示了下丘脑.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 睡眠医学 睡眠医学
背景情况:
- 睡眠困难,包括启动和维持问题,在自闭症患者中很普遍.
- 已知皮下大脑区域,特别是下丘脑,对于睡眠调节至关重要.
- 睡眠,皮下结构和幼儿行为症状之间的相互作用需要进一步研究.
研究的目的:
- 研究2~4岁的自闭症和非自闭症儿童的皮质下大脑体积和睡眠启动/维持之间的关联.
- 检查这些关联中的外部化和内部化症状的调解作用.
- 为了确定早期儿童睡眠失调的神经生物学相关性.
主要方法:
- 磁共振成像 (MRI) 用于评估203名自闭症和92名非自闭症儿童 (年龄为24岁) 的皮质下大脑体积.
- 睡眠的启动和维持使用儿童睡眠习惯问卷的经过验证的子尺度进行了测量.
- 使用儿童行为检查清单-学前班评估了外部化和内部化症状,并采用了调解分析.
主要成果:
- 较小的右下丘脑体积与自闭症和非自闭症儿童的失调睡眠启动和维持显著相关.
- 外化行为,而不是内化行为,部分介导了右下丘脑体积和睡眠问题之间的关联.
- 右下丘脑体积和睡眠困难之间的关联强度在自闭症和非自闭症组之间是可比的.
结论:
- 右下丘脑在自闭症和非自闭症幼儿的睡眠启动和维持中起着至关重要的作用.
- 外向化行为与下丘脑结构和睡眠调节之间的关系有关.
- 研究结果强调了考虑神经生物学和行为因素在解决早期儿童睡眠困难时的重要性.
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