母体铁状况与先天性心脏缺陷风险之间的关系:一个病例对照研究
Raghdah Qaddour1, Ranwa Alsayed1
1Department of Biochemistry and Microbiology, Damascus University, Syria.
The Journal of international medical research
|July 9, 2025
概括
孕产妇缺铁与婴儿患先天性心脏缺陷的风险更高有关. 这项研究发现,患有心脏缺陷的婴儿的母亲的铁含量较低,铁缺乏症增加.
科学领域:
- 心脏病学 心脏病学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 营养科学 营养科学
背景情况:
- 先天性心脏缺陷 (CHD) 是一个重要的全球健康问题,在大多数情况下原因不明.
- 以前的小鼠研究表明,母体缺铁与心血管疾病之间存在联系,但对人类的数据有限.
研究的目的:
- 调查母亲的铁状况与婴儿先天性心脏缺陷的发生之间的联系.
- 为了确定母亲的铁缺乏是否是人类婴儿心血管疾病的风险因素.
主要方法:
- 对70名患有心脏病的婴儿的母亲 (病例组) 和30名没有心脏病的婴儿的母亲 (对照组) 进行了病例控制研究.
- 采访母亲和外围血液样本用于分析铁的生物标志物.
- 双项逻辑回归被用来计算母亲的铁状况与慢性病之间的关联的几率比率.
主要成果:
- 与对照组相比,病例组中的母亲表现出明显较低的血清费里,血清铁和转激素和,以及较高的总铁结合能力 (p < 0.05).
- 患有冠状动脉疾病的婴儿的母亲的铁缺乏症风险增加了近三倍 (OR = 2.91,95% CI: 1.143-7.418).
结论:
- 在被诊断患有先天性心脏缺陷的婴儿的母亲中,母亲的铁状况明显较低.
- 孕产妇缺乏铁的可能性显著高于婴儿先天性心脏缺陷的可能性.
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