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Updated: Sep 16, 2025

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一个可切换的开关门现象在Dipalmitoylphosphatidylcholine Bilayers中,由特拉赫兹波控制

Tao Zhang¹, Zi Wang¹, Shuang Li¹

¹MIIT Key Laboratory of Semiconductor Microstructure and Quantum Sensing, and Department of Applied Physics, Nanjing University of Science and Technology, Nanjing 210094, China.

The journal of physical chemistry. B

|July 9, 2025

概括

太赫兹 (THz) 波可以通过微妙地改变双基酸胆 (DPPC) 双层结构来调整细胞膜的透性. 这种非侵入性方法为生物应用提供可控的开关.

科学领域:

生物物理学的生物物理.
膜生物物理学膜生物物理学
在THz光谱学.

背景情况:

细胞膜的透性对于生物过程至关重要,如药物输送和病毒进入.
在细胞膜中常见的双层二甲基酸胆 (DPPC) 由于其疏水性,具有较低的水透性.
现有的改变膜透性的方法可能是侵入性的或缺乏精确的控制.

研究的目的:

研究太赫兹 (THz) 波对DPPC双层结构和透性的影响.
探索THz波作为调节膜特性的一种非侵入性工具的潜力.
了解THz诱导DPPC双层变化的潜在机制.

主要方法:

用分子动力学模拟来建模DPPC双层.
模拟是在不同的太赫兹 (THz) 波场强度和频率下进行的.
使用潜在的平均力 (PMF) 计算来评估水透障碍.

主要成果:

太赫兹 (THz) 波诱导DPPC分子和更松散的双层排列中的微妙结构变化.
观察到平均力 (PMF) 屏障对水透的潜力显著降低.
DPPC双层在响应THz波刺激时显示出可控制的"开启-关闭"关行为.
在THz波暴露期间,DPPC双层的结构完整性得到维持.

结论:

太赫兹 (THz) 波提供了一种有效的,非侵入性的策略来调整生物膜的透性.
两层DPPC和THz波之间的共振是改变透性的关键机制.
这一发现为开发利用THz技术的新生物和生物医学应用开辟了新的途径.

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