在pH,时间和结肠细菌酶触发的聚合物之间进行比较研究,用于结肠输送涂层胺多颗粒物
Debaprasad Ghosh1, Ashu Mittal1, Mandeep Kumar Arora2
1Department of Pharmaceutics, KIET School of Pharmacy, Ghaziabad (Affiliated to Dr. APJ AKTU, Lucknow), Ghaziabad, Uttar Pradesh, India.
Drug development and industrial pharmacy
|July 9, 2025
概括
这项研究比较了托颗粒的各种涂层,以实现有针对性的结肠输送. 基于多糖的涂层证明了最有效和高效的结肠向药物释放.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 结肠药物向是针对结肠药物向的
背景情况:
- 开发用于结肠输送的胺颗粒.
- 对控制释放的不同涂层机制的评估.
研究的目的:
- 对比pH依赖,时间依赖和酶降解依赖的涂层用于结肠向.
- 确定甲颗粒的最有效的涂层策略.
主要方法:
- 使用粉末分层制备含有药物的颗粒.
- 用Eudragit,基烯纤维素,乙烯纤维素和pectin涂层颗粒.
- 在体外评估包括溶解研究.
- 在子体内使用X射线和马光谱进行体内评估.
主要成果:
- 药物聚合物兼容性通过FTIR和DSC证实.
- 在上部消化道中释放有限的优化丁和乙烯纤维素涂层颗粒 (16.7%).
- 高剂量药物释放 (91.6%) 在结肠中达到高效的胃肠运输.
结论:
- 基于多糖的配方在向性结肠药物输送方面显示出显著的前景.
- 优化的涂层有效地准结肠,以提高治疗效果.
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