植物酸通过皮肤微生物群衍生的-3-酸改善皮肤屏障功能,在Atopic皮肤炎的小鼠模型中通过皮肤微生物群衍生的-3-酸
Piao Wang1, Lan Yang1, Lu Chen1
1Department of Plastic and Aesthetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.
Allergy
|July 9, 2025
概括
植物酸 (PA) 通过改变皮肤微生物代谢物来改善亚托皮炎 (AD) 中的皮肤屏障功能. 这突出了PA作为AD治疗的潜在治疗策略.
科学领域:
- 皮肤病学 皮肤病学
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
背景情况:
- 亚托匹性皮肤炎 (AD) 的发病包括皮肤屏障功能障碍和皮肤障碍症.
- 作为饮食成分的植物酸 (PA) 在AD中的作用尚不清楚.
研究的目的:
- 研究PA改变的皮肤微生物代谢物对AD的影响.
- 探索PA在AD中的作用的具体机制.
主要方法:
- 使用MC903诱导的AD小鼠模型.
- 使用跨皮肤脱水 (TEWL),免疫光和qPCR评估效应.
- 通过16S rRNA测序,RNA-seq,LC-MS/MS,光酶试验和siRNA实验来研究这些机制.
主要成果:
- 在AD模型中,饮食衍生的PA显著改善了皮肤屏障功能.
- 局部PA应用重塑了皮肤微生物群,增加了像Staphylococcus epidermidis这样的酸盐代谢细菌.
- 酸可上调醇衍生物 (例如,醇-3-酸),激活酸受体 (AHR) 并促进KRT10转录,从而改善AD.
结论:
- 饮食衍生的PA通过调节皮肤微生物群代谢物来增强AD屏障功能.
- 帕代表了治疗亚托皮性皮肤炎的新治疗策略.
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