欧米茄-3多不和脂肪酸和人类脂肪组织炎症:一个范围审查
Ji-Eun Chon1, Kira Zhi Hua Lai1, Zhila Semnani-Azad1,2
1Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 3K3, Canada.
Nutrition reviews
|July 9, 2025
概括
欧米茄-3脂肪酸可以减少脂肪组织的炎症,但人类研究是有限的和不一致的. 需要更多的研究来证实n-3多不和脂肪酸 (PUFA) 对脂肪组织健康的益处.
科学领域:
- 营养科学 营养科学
- 炎症研究 炎症研究
- 代谢健康 代谢健康
背景情况:
- 脂肪组织 (AT) 炎症与全身亚临床炎症有关.
- 在临床前模型中,n-3多不和脂肪酸 (PUFA) 显示出降低AT炎症的前景.
- 人类对n-3PUFA和AT炎症的数据稀缺且不一致.
研究的目的:
- 进行关于n-3PUFA和AT炎症之间的关系的人类研究的范围审查.
- 识别,审查和绘制健康成年人的现有文献.
- 评估当前的证据基础,并确定研究缺口.
主要方法:
- 在2022年8月4日之前搜索了MEDLINE,EMBASE和Cochrane数据库.
- 包括实验试验和健康的非怀孕成年人的观察性研究.
- 选并提取与AT炎症相关的研究特征和结果的数据.
主要成果:
- 包括25项研究,显示了设计和方法的显著异质性.
- 观察性研究始终报告了n-3PUFA和AT炎症标志物之间的显著关联.
- 在20项实验试验中,15项显示n-3PUFA对至少一个结果有显著影响,但结果不一致.
结论:
- 目前关于n-3PUFA和AT炎症的人类文献是不确定的.
- 研究数量有限和设计异质性阻碍了最终的结论.
- 建议使用直接AT措施进行更大,更长期的研究.
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