胰腺外分缺陷在乳病中并不罕见:系统性审查和元分析
Miroslav Vujasinovic1,2, Nina Blazevic3, Patrick Maisonneuve4
1Department of Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden.
United European gastroenterology journal
|July 9, 2025
概括
胰腺外分缺陷 (PEI) 影响大约13.5%的患有乳病 (CeD) 的人. 这种患病率在未经治疗的CeD患者中更高,并且在不响应的情况下需要考虑PEI.
科学领域:
- 胃肠病学 胃肠病学
- 消化系统健康 消化系统健康
- 临床研究 临床研究
背景情况:
- 胰腺外分缺陷 (PEI) 与主要胰腺疾病和胰腺外疾病 (如乳病) 有关.
- PEI和CeD重叠的症状使诊断复杂化.
- 这项研究系统地审查了CeD患者PEI的患病率.
研究的目的:
- 在被诊断患有乳病 (CeD) 的个体中确定胰腺外分缺陷 (PEI) 的患病率.
- 分析不同年龄组的PEI患病率和CeD人口中的治疗状态.
主要方法:
- 在五个主要数据库中进行了系统的文献搜索,截至2024年10月21日.
- 包括的研究涉及生物检测证实的腹腔疾病.
- 计算了PEI的综合流行率,并评估了研究质量.
主要成果:
- 十二项研究符合纳入标准,分析了1432篇出版物.
- 在CeD中,PEI的综合加权总体患病率为13.5%.
- 患病率在儿童 (14.2%) 和成年人 (12.8%) 中是相似的,并且在未经治疗的CeD患者中 (18.2%) 与无质饮食 (6.9%) 患者相比显著更高.
结论:
- 大约八分之一的患有乳病的人可能会经历胰腺外分泌功能不全.
- 尤其是PEI在未经治疗的乳病中更为普遍.
- 对于不对无质饮食有反应的乳病患者,建议考虑PEI.
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