怀孕期间接触非法物质和婴儿死亡风险:台湾全国性研究
Chun Lin1, Mu-Hong Chen2,3, Wei-Szu Lin4
1Kunming Prevention and Control Center, Taipei City Hospital, Taipei, Taiwan.
The international journal of neuropsychopharmacology
|July 9, 2025
概括
产前非法物质的使用,特别是多种物质,如甲基胺和阿片类药物,显著增加婴儿死亡风险. 怀孕期间使用多种物质与更高的婴儿死亡率有关,这突显了严重的公共卫生问题.
科学领域:
- 围产期健康 围产期健康
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 调查产前接触非法药物和婴儿死亡率之间的联系.
- 澄清特定/多种物质使用与增加婴儿死亡之间的关联.
研究的目的:
- 检查产前暴露于非法物质和婴儿死亡率之间的关联.
- 确定与较高死亡风险相关的特定物质和使用模式.
主要方法:
- 在台湾 (2004-2019) 进行了1,937,301次出生的回顾性队列研究.
- 包括11,477名非法毒品使用者和匹配的对照.
- 使用考克斯回归来分析所有原因的婴儿死亡率,按物质类型和暴露时间分层.
主要成果:
- 使用非法药物的母亲的婴儿的死亡率比对照 (0.4%) 高 (0.7%).
- 多种物质的使用 (通常是甲基胺/阿片类药物) 显著增加死亡风险 (aHR 1.53).
- 没有任何单一物质显示出统计学上显著的关联;风险随着早期/怀孕中期暴露时间的增加而增加.
结论:
- 产前非法物质使用与高1岁婴儿死亡率有关.
- 多重物质使用具有最高的死亡风险.
- 调查结果强调了针对有毒物质使用障碍的孕妇进行有针对性的干预的必要性.
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