系统性红斑狼妊娠不良后果的危险因素:元分析和系统性审查
1Department of Rheumatology and Immunology, Hangzhou Normal University Affiliated Hospital, Hangzhou, 310015, China.
Archives of gynecology and obstetrics
|July 9, 2025
概括
系统性红斑狼 (SLE) 怀孕面临高血压,狼性炎 (LN) 和抗脂综合征 (APS) 的风险. 识别这些因素有助于早期干预,以改善母亲和胎儿的结果.
科学领域:
- 产科和妇科 产科和妇科
- 类风湿病学 类风湿病学
- 周围生理学 周围生理学
背景情况:
- 系统性红斑狼 (SLE) 是一种自身免疫性疾病,与不良妊娠结果 (APO) 密切相关.
- 关于SLE怀孕中APO风险因素的先前研究受到区域范围和小样本大小的限制.
- 综合性系统性审查很少,这凸显了需要更广泛的分析.
研究的目的:
- 进行严格的元分析和系统审查,以确定系统性红斑狼 (SLE) 影响的怀孕中不良妊娠结果 (APO) 的风险因素.
- 解决现有的研究差距,以全面识别SLE怀孕中APO风险因素.
主要方法:
- 在PubMed,Embase,Web of Science和Cochrane图书馆进行了系统的文献搜索,截至2025年3月25日.
- 基于异质性的固定或随机效应模型 (I2) 计算了聚合赔率比率 (OR).
- 使用埃格尔的测试来评估出版偏见.
主要成果:
- 审查了43项研究,确定高血压,狼性炎 (LN),高疾病活性,低补充剂和抗脂综合征 (APS) /抗脂抗体 (aPL) 作为APO的主要风险因素.
- 过早分娩的特定危险因素包括LN,高血压,疾病爆发,高疾病活力和APS/aPL.
- 流产与APS/aPL,低补充剂,疾病爆发,LN,高血压,血小板缺血和高疾病活性有关. LN还增加了子宫内生长限制和低出生体重的风险.
结论:
- 这次元分析确定了SLE怀孕中不良妊娠结果的显著风险因素.
- 这些发现可以帮助早期识别高风险个体.
- 基于这些已识别的风险因素的及时干预可能会改善母亲和胎儿的结果.
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